Brainy days

Whew, we’re done with a week of meeting smart folks and learning about the brain. More than 31,000 neuroscientists hit DC last week, and a lot of us wrote about it. Here are my entries for The Dana Foundation:

How Do You Get Involved in Neuroethics?
During a workshop at the annual meeting of the International Neuroethics Society, panelists advised ethical wannabes to just get started.

Sex (differences) and Brain Science
Is the study of sex differences gaining traction in neuroscience? It was the topic of the very first Social Issues Roundtable at the Society for Neuroscience, in 1983, and it was the topic again this year.

Generating Obesity
The obesity epidemic was the topic of the Public Advocacy Forum at the Society for Neuroscience annual meeting on Wednesday, and it was nearly two hours of scary data with a little bit of hope.

New vocabulary

Brain scientists occupy DC

Smack in the middle of National Novel Writing Month, I have to switch gears for a week to report on the news in brain science (that’s my day-job). Neuroscience 2011 is the big event of the year for these folks. Starting Saturday, more than 30,000 scientists from around the world are expected to converge on the Walter E. Washington Convention Center in Washington, DC, to present and discuss cutting-edge research on the brain and nervous system.

This is my sixth time attending (as a member of the press, not a brain expert), and I love to soak up the enthusiasm and cheerful argumentitiveness of these passionate folks. And boy, do I learn a lot. The event is organized by the people at the Society for Neuroscience (SfN), whom we work with on many projects, especially Brain Awareness Week (BAW). On Saturday, we’ll be presenting during the Brain Awareness campaign meeting, at 3 pm in the Convention Center’s Room 151.

There is always a ton of new research at the conference; some of it is incremental or not-yet-ready-for-publication, but don’t be surprised if you see a lot of news stories on brain topics this weekend.

At the Dana Foundation blog, we’ll be reporting from the event over the next few weeks, but if you want to follow an up-to-the-minute feed hop onto Twitter: The official conference hashtag is #sfn11. Nature is planning a lot of coverage, starting at its blog Action Potential and via Google+. If you’re interested in specific topics, you might follow one of SfN’s official neurobloggers, who are focusing on various themes, from nervous-system disorders to history and teaching.

I attended one of the auxiliary events already, on Thursday and Friday, the annual meeting of the International Neuroethics Society. My story, “How do you get a job in neuroethics?” is up, at dana.org.

Where do you get your ideas?

As part of my prep for National Novel Writing Month (nanowrimo.org), which starts next week (eek!), I’m reading through issues of the London Times from 1808. My story this time will be that of a British journalist sent to Spain to cover the start of the campaign there against the French. Amongst the reports on the Spanish war and the lifting of the tax on coffee, I found this item:

SUICIDE.—A beautiful young woman, who was recently the adored of a certain Marquis, and who has since been under the protection of a military officer, put a period to her existence at her apartments, a draper’s, in Oxford-street, on Sunday night, by taking a considerable portion of laudanum. Her last protector had dined and spent the day with her on Sunday, and after his departure, at 11 o’clock at night, the lady was found in tears, and much dejected. She was found dead in her bed at nine o’clock on Monday morning, and it was ascertained, that she had taken a tea-cup full of the poisionous liquid.

(The Times, 8 October 1808, p. 3)

Uh-oh. I feel another story coming on.

The Blasted Brain

[by me for the Dana Foundation blog. See more great stuff there!]

Traumatic brain injury (TBI), the signature injury of the current U.S. wars, calls for the nation’s best “emergency medicine,” Kevin Kit Parker told a group of top scientists, medicine makers, and policy makers, this spring at the One Mind for Research conference in Boston.

“Certainly TBI, as it affects the force, is a national security issue, and it’s certainly an emergency issue.” Like the race to the moon and the Manhattan project, he said, TBI is an emergency science project with national security at stake and a need to move rapidly.

“You’ve got young NCOs [non-commissioned officers], young soldiers out there that have been blown up a dozen times, a dozen times they’ve suffered a traumatic brain injury, since 9/11. We have this growing cadre of our professional warriors that are out there, that are walking around, and the concern is, what does the future hold for them?”

The timelines of TBI damage range from nanoseconds to years. “The data now is pretty clear that TBI can potentiate a variety of neurodegenerative diseases, including Parkinson’s and Alzheimer’s disease,” Parker said. “So the outlook for these young soldiers is kind of bleak right now.”

Parker, a professor at Harvard, has also served multiple tours in Afghanistan in the Army Reserve, tending the wounded immediately after impact and observing their recovery on base and back in the United States. The experiences led him to expand his research focus from the physics of the heart to the brain. “When people started trying to kill me with IED’s I thought I’d better get a piece of this,” he said.

His background also led to an unusual approach to the problem, or at least unusual for neuroscientists. “I’m an infantry officer in the reserve, and I’m not a physician, I’m a physicist, so I look at things in terms of scaling laws.” Interested in how mechanical energy (such as from blasts) affects neurons, he and the people in his lab decided to try to build physical models of blast injury from molecule to cell and from cell to tissue.

“We use tissue engineering as a tool, including blasting neurons,” he said. “What we found right away is that we can mimic some of the things that the neuropathologists are reporting that they’re seeing in patients.”

“Now that we’ve got all these models, we’re working on developing a systematic understanding of the mechanical forces required to injure these neurons, these vascular tissues, and understand the chemical cascades that are turned on by these mechanical forces.” If they understand these chemical cascades, they could start to identify which molecules along the cascade are the most vulnerable—and which might be easily reached by drugs and other therapies.

Part of emergency medicine is exploring many avenues simultaneously, Parker said. His theory is it’s diffused axonal injury that leads to damage from TBI, but researchers need to work on multiple hypotheses, to “flank the problem” with the outside-the-box ideas until someone finds some badly needed solutions.

One giant challenge: “We need to build a brain,” he said. “Everyone would benefit from having a brain in their [laboratory] dish to work on:” a 1 mm3 piece of brain that mimics the neural microenvironment, scalable so what people discover in the lab can be tested in drug-maker’s wide-assay studies. He’s working on it.

In addition, “we need to push the science as far forward [on the battlefield] as we possibly can,” he said. “It might be a diffusion tensor imager that we put downrange, it might be a biomarkers lab that we put downrange … so we can understand, as these soldiers come off the battlefield, what’s happening to them, rather than waiting 6 months, 12 months before they present at a VA emergency room.”

“The whole idea is that when these guys [medics] run up there to pull these broken kids out of this MRAP [armored vehicle], that there’s a whole team behind them supporting them,” he said. “If I run up there and this kid’s got a leg dangling off, I know how to apply a tourniquet to him. If I run up there and he’s got his bell rung, I got no way of treating this guy right now. And right now he’s at the genesis of these neurodegenerative diseases that might not appear for 20-30 years down the road.”

His remarks start just after minute 1 of this video. The slides he uses are especially useful in understanding the science.

The forum was held in Boston May 23–25 by the One Mind for Research campaign, whose goal is “to significantly reduce the U.S. burden of disability due to brain disorders.” The campaigners released a blueprint of research goals at the event: “A Ten-Year Plan for Neuroscience: From Molecules to Brain Health” (PDF). Videos of all the sessions are collected on the Science Network site.

The Science Network also did a wide-ranging interview with Parker, on work in the lab, his experience in Afghanistan, how he got started in science, and his passionate advocacy for his compatriots in the field. (22 min). It’s also well worth a listen.

–Nicky Penttila

More Aspen!


Best part of hiking the park trails in town is all the “hidden” art along the paths. Plus, on a Monday, almost nobody was on the trails! It is easy to meditate in Aspen.



One kind soul did wander by so I could ask him to take my picture. He was one of the few on the trail who did not have a giant (but well-behaved) dog. I saw one big Jeepish car with 3 big dogs in the back seat, hanging their heads out the windows, and another big dog doing the same from the passenger seat.

Crocs enjoy the view from my back porch at the Hotel Aspen. Sadly, crocs are not in style in Aspen — it’s flip-flops, duh. So many women out at night in fall outfits, wrapped in jackets and thick scarves, and flip-flops on their feet.

Aspen!

shoes atop Ajax Mountain, Aspen

These shoes once trod upon Machu Picchu, but this weekend they surmounted Ajax Mountain in Aspen. (They were made from recycled tires, so who knows where else they have been). Unsurprisingly, I was the only one clad completely in black hiking the tyro trail Sunday afternoon; dressed for texture and not color this morning.

The camera battery went dim, but I still managed a shot as we rode the gondola back into town.

Here’s why I was here, the second Aspen Brain Festival, at the Aspen Institute. Dana sent me this year because the theme was neuroeducation, which we’re hot on. Stay tuned for my reporting from the forum, and a cool podcast in a month or so.

Active Learning

[by me for the Dana Foundation blog. See more great stuff there!]

Despite falling SAT scores and employers reporting that high-school grads can’t run the cash register, researchers, educators, and parents each have some pieces of the puzzle of how children learn best. But somehow, all these experts don’t always share what they know.

Consider the power of playful learning. While research shows that unstructured play promotes attention and critical thinking skills and exercise can reduce stress and help prevent obesity, some schools are dropping recess and cutting back on playtime. At home, some parents equate playtime with wasted time, even though imaginative play, like planning and holding a pretend tea party, helps children practice social conversation and completing tasks in order.

How do we change their minds? That’s the task the Learning Resources Network, or L_rn, has taken on. Its first big project was the highly successful Ultimate Block Party in New York’s Central Park last fall; event planners expected a few thousand families and instead drew more than 50,000. Even The New York Times took notice, albeit a few months later. Local leaders repeated its success recently in Toronto, and on Sunday afternoon, Oct. 2, Baltimore Public Schools will host the third party, on Rash field in Baltimore’s Inner Harbor.

“We want to share the science,” said Roberta Michnick Golinkoff of the University of Delaware during a forum on the project on Wednesday. “We know how kids learn best; it’s out there, it’s not a secret anymore.”

This four-minute video from last year tells their story, from problems to solutions:

“We want to show the science of learning through play,” said L-rn’s Publisher Susan Magsamen of Johns Hopkins University during a forum on Wednesday. The Ultimate Block Party is an application of these principles in the real world, and next month the group will launch an application in the virtual world, the Web portal l-rn.com.

Even though I’m not a kid anymore, I’m planning to go to the party in Baltimore. Learning is lifelong, after all. And, as I wrote for the Baltimore magazine Urbanite back in 2006, many of us, of all ages, could use more play in our lives.

Where are we with pain?

At one session at a forum put on by One Mind for Research in Boston last spring, researchers described progress in treating the invisible wounds sustained by the brain, including post-traumatic stress disorder, concussions, and chronic pain (see earlier post: “Targeting the Effects of War on the Brain“). I learned a lot at the forum, but one comment by presenter Clifford J. Woolf, director of the program in neurobiology at Children’s Hospital Boston, especially jumped out at me.

While we have made enormous progress in promoting survival after injury and great advances in rehabilitation, he said, “in fact an area that has really lagged behind relates to the pain associated with combat injury.” I wanted to know more: Where are we in our ability to identify and treat this very common but frustratingly individual ailment?

I assigned reporter and author Kayt Sukel to investigate further. We’ve just posted her story “Is the Neuroscientific Study of Pain Lagging?” Short answer: We have been stuck but now with new tools we might tease out some answers sooner rather than later. Find out more at www.dana.org.

–Nicky Penttila

No Expiration Date on PTSD

Even though I live near Washington, DC, I’m not a politics maven. I remember when Sen. Max Cleland lost his seat in 2002, but I hadn’t heard anything about him since, so I figured he had happily retired from the often-dirty fray. I could not have been more wrong.

I saw him again last month when he spoke to the researchers, biotech workers, and advocates at the “Next Frontier of the Brain” forum in Boston. Instead of relaxing after his decades of public service, Cleland had spiraled down into the abyss of PTSD—more than 40 years after he was grievously wounded in Vietnam.

“People who overcome, especially, physical injuries…usually do it by means of having some kind of purpose in their life. I had a strong meaning and purpose; it was called politics, government service.”

“But then I lost [the election]. I lost my sense of meaning and purpose and destiny, vision. And at that point, then the reality of the wounding came into play. Then I realized, only recently, I was dealing with something that was much bigger than I was. And that was the basic, fundamental aspect of your brain.

“I went down into a massive, deep, dark depression sparked by massive anxiety and what we now know flooding of adrenaline and cortisol into the system—and all of that stuff came flooding back from forty-some-odd years ago, just like I was on the battlefield again, dying, overwhelmed, overcome.” At one point, he said, he was so disabled, emotionally and cognitively, that he lost the ability to read.

Cleland went back to Walter Reed hospital, where he had first recovered from the loss of parts of three limbs in 1968. This time, the doctors helped him start to heal his inner wounds. “Thank God, patient help, trauma counseling at Walter Reed…anti-depressant for a while, I began to recover. And I’m beginning to restore my sense of self and all these other things, and then, you know, magically the emotions come back, and the cerebral capability comes back, and then you begin to start thinking again about meaning and purpose.”

Cleland also tells his story in the documentary film Halfway Home, which follows several veterans through their first years home from war. The film had its Boston premiere as part of the forum; its director, Paul Freedman, and narrator, Martin Sheen, joined Cleland to talk about the film after the showing.

In the film, Cleland describes one of his low moments at Walter Reed, sitting and sobbing uncontrollably and then hearing, through the wall, his own voice, cheerful. It was from a video he had recorded long ago to inspire newly wounded patients to not give up.

“I had no idea for years, for decades, that I might have some kind of something called post-traumatic stress disorder,” he said at the forum. “For those who have been wounded, whether they have been physically wounded or not, when they have been traumatized, that old horse, that thousand-pound steed in your mind, has been spooked. It has been spooked. And if it has been spooked numerous times, it ain’t ever forgetting.”

“And so anything that comes along and spooks that horse—we call it triggers, nowadays—then you’re off and running. You’re liable to be thrown off the horse and dragged along the ground.”

Now Cleland is secretary of the American Battle Monuments Commission and, as always, a strong advocate for veterans. And he wrote a book about his journey, Heart of a Patriot: How I Found the Courage to Survive Vietnam, Walter Reed and Karl Rove. He ended his remarks with a plea to the audience: “Those of us that have made that journey and hundreds of thousands, really, millions of young Americans who have put their lives on the line for the rest of us, need you. We need you.”

His remarks start just after the first minute of this video; researchers on pain, PTSD, and concussion follow (here you can find a description of those presentations). Video and mp3 audio also available on The Science Network site.

The forum was held in Boston May 23–25 by the One Mind for Research campaign, whose goal is “to significantly reduce the U.S. burden of disability due to brain disorders.” The campaigners released a blueprint of research goals at the event: “A Ten-Year Plan for Neuroscience: From Molecules to Brain Health” (PDF). Videos of all the sessions and interviews are collected on the Science Network site.

Just before I left to travel to the conference, I read in my local paper of a hit-and-run driver who had killed a pedestrian in the dark of night. The top of the story described the accident and suggested alcohol was involved. In the middle of the story, I read that the driver, who was found disoriented in a nearby field, was a friend of the person he had allegedly hit; they were both headed home in the same neighborhood. At the end of the story, I learned that the driver was recently returned from a war zone. Now when I hear these stories, I wonder: Was he showing symptoms of PTSD? Was he getting the re-entry care he needed? Are there others like him we must help?

[This post first appeared on the Dana Foundation blog; find more great stuff there!]

Writers do New York

Romance Writers of America has taken over the Marriott Marquis in Times Square for its annual convention this year. This year’s theme is “Bright Lights, Big Stories,” and with more than 2,100 writers attending, there are a lot of great stories here. And books — I have three dozen already. Need another suitcase!
Here’s the view from my window:

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